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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T19355 | Heparan Sulfate | FGFR , Wnt/beta-catenin , Endogenous Metabolite | |
Heparan Sulfate, a complex and linear polysaccharide, forms a component of glycoproteins called heparan sulfate proteoglycans, abundantly expressed on the cell surface and within the extracellular matrix. | |||
T16380 | OGT 2115 | Others | |
OGT 2115 is an inhibitor of heparanase (IC50 = 0.4 µM), an enzyme that cleaves heparan sulfate into glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc). OGT 2115 also showed antiangiogenic properties (IC50=1 μM). | |||
T69224 | Hemisurfen | ||
Hemisurfen is a small molecule, surfen derivative with heparan sulfate antagonist properties. | |||
T36111 | L-Iduronic acid sodium salt | ||
L-Iduronic acid sodium salt is a monosaccharide that is an important component of glycosaminoglycans (GAGs) such as heparin, heparan sulfate, and dermatan sulfate. | |||
T81940 | Lepunafusp alfa | JR-171 | |
Lepunafusp alfa (JR-171) is a blood-brain barrier-penetrating fusion protein comprising J-Brain Cargo and α-L-iduronidase (IDUA), a lysosomal enzyme. This compound effectively lowers the levels of heparan sulfate (HS) an... | |||
TP1555 | Fibronectin Active Fragment Control | ||
Fibronectin is a high-molecular weight (~440kDa) extracellular matrix glycoprotein that binds to membrane-spanning receptor proteins called integrins.In addition to integrins, fibronectin also binds extracellular matrix ... | |||
T81573 | Pabinafusp alfa | JR-141 | |
Pabinafusp alfa (JR-141), a transferrin receptor-targeting antibody fusing Iduronate 2-sulfatase with an anti-human transferrin receptor antibody, penetrates the blood-brain barrier and inhibits heparan sulfate (HS) accu... |